8EGD

Branched chain ketoacid dehydrogenase kinase in complex with inhibitor

Summary for 8EGD

• Entry DOI: 10.2210/pdb8egd/pdb
• Descriptor: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: branched-chain ketoacid dehydrogenase, branched-chain ketoacid dehydrogenase kinase, inhibitors, angiotensin receptor blocker, complex, signaling protein
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 1
• Total formula weight: 45568.90

Authors

Liu, S. (deposition date: 2022-09-12, release date: 2023-03-08, Last modification date: 2023-10-25)

• Primary citation: Liu, S.,Kormos, B.L.,Knafels, J.D.,Sahasrabudhe, P.V.,Rosado, A.,Sommese, R.F.,Reyes, A.R.,Ward, J.,Roth Flach, R.J.,Wang, X.,Buzon, L.M.,Reese, M.R.,Bhattacharya, S.K.,Omoto, K.,Filipski, K.J.; Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.; J.Biol.Chem., 299:102959-102959, 2023; PubMed: 36717078; DOI: 10.1016/j.jbc.2023.102959

Experimental method

X-RAY DIFFRACTION (2.047 Å)