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8EGD

Branched chain ketoacid dehydrogenase kinase in complex with inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0004740molecular_functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
A0005524molecular_functionATP binding
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006550biological_processisoleucine catabolic process
A0006552biological_processL-leucine catabolic process
A0006574biological_processvaline catabolic process
A0007283biological_processspermatogenesis
A0008610biological_processlipid biosynthetic process
A0009083biological_processbranched-chain amino acid catabolic process
A0010510biological_processregulation of acetyl-CoA biosynthetic process from pyruvate
A0010906biological_processregulation of glucose metabolic process
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016772molecular_functiontransferase activity, transferring phosphorus-containing groups
A0045252cellular_componentoxoglutarate dehydrogenase complex
A0047323molecular_function[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
A0106310molecular_functionprotein serine kinase activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:11562470, ECO:0007744|PDB:1GKZ
ChainResidueDetails
AASN249
ALEU340
AASP285
AVAL298
AASP300
APHE303
ATHR304
ATHR305
AHIS334
AGLY337

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:7649998, ECO:0007744|PubMed:22673903
ChainResidueDetails
ASER1

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O14874
ChainResidueDetails
ALYS162
ALYS203

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ASER326
ASER330

227344

PDB entries from 2024-11-13

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