8EG5

huCaspase-6 in complex with inhibitor 3a

8EG5 の概要

• エントリーDOI: 10.2210/pdb8eg5/pdb
• 分子名称: Caspase-6 subunit p18, Caspase-6 subunit p11, (3R,5S)-1-(ethanesulfonyl)-5-phenyl-N-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxamide (bound form), ... (5 entities in total)
• 機能のキーワード: cysteine covalent inhibitor competitive inhibitor protease, apoptosis, protease-protease inhibitor complex, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 121229.13

構造登録者

Zhao, Y.,Fan, P.,Liu, J.,Wang, Y.,Van Horn, K.,Wang, D.,Medina-Cleghorn, D.,Lee, P.,Bryant, C.,Altobelli, C.,Jaishankar, P.,Ng, R.A.,Ambrose, A.J.,Tang, Y.,Arkin, M.R.,Renslo, A.R. (登録日: 2022-09-11, 公開日: 2023-05-10, 最終更新日: 2023-10-25)

• 主引用文献: Van Horn, K.S.,Wang, D.,Medina-Cleghorn, D.,Lee, P.S.,Bryant, C.,Altobelli, C.,Jaishankar, P.,Leung, K.K.,Ng, R.A.,Ambrose, A.J.,Tang, Y.,Arkin, M.R.,Renslo, A.R.; Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6.; J.Am.Chem.Soc., 145:10015-10021, 2023; PubMed: 37104712; DOI: 10.1021/jacs.2c12240

実験手法

X-RAY DIFFRACTION (2.14 Å)