8EDE

Crystal structure of covalent inhibitor 2-chloro-N'-(N-(4-chlorophenyl)-N-methylglycyl)acetohydrazide bound to Ubiquitin C-terminal Hydrolase-L1

8EDE の概要

• エントリーDOI: 10.2210/pdb8ede/pdb
• 分子名称: Ubiquitin carboxyl-terminal hydrolase isozyme L1, 2-[(4-chlorophenyl)-methyl-amino]-~{N}'-ethanoyl-ethanehydrazide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: uchl1, deubiquitylating enzyme, inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50606.34

構造登録者

Patel, R.,Imhoff, R.,Flaherty, D.,Das, C. (登録日: 2022-09-04, 公開日: 2023-09-20, 最終更新日: 2024-04-10)

• 主引用文献: Imhoff, R.D.,Patel, R.,Safdar, M.H.,Jones, H.B.L.,Pinto-Fernandez, A.,Vendrell, I.,Chen, H.,Muli, C.S.,Krabill, A.D.,Kessler, B.M.,Wendt, M.K.,Das, C.,Flaherty, D.P.; Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1.; J.Med.Chem., 67:4496-4524, 2024; PubMed: 38488146; DOI: 10.1021/acs.jmedchem.3c01661

実験手法

X-RAY DIFFRACTION (1.799 Å)