8EC9

Covalently stabilized triangular trimer derived from Abeta16-36 with p-iodo-phenylalanine

This is a non-PDB format compatible entry.

Summary for 8EC9

• Entry DOI: 10.2210/pdb8ec9/pdb
• Descriptor: ORN-LYS-LEU-VAL-PHI-PHE-ALA-GLU-ORN-CYS-ILE-ILE-SAR-CYS-MET-VAL (2 entities in total)
• Functional Keywords: abeta oligomer, beta-hairpin, trimer, dodecamer, alzheimer's disease, de novo protein
• Biological source: synthetic construct
• Total number of polymer chains: 6
• Total formula weight: 11653.30

Authors

Kreutzer, A.G.,Yoo, S.,Nowick, J.S. (deposition date: 2022-09-01, release date: 2023-05-31, Last modification date: 2023-06-07)

• Primary citation: Kreutzer, A.G.,Guaglianone, G.,Yoo, S.,Parrocha, C.M.T.,Ruttenberg, S.M.,Malonis, R.J.,Tong, K.,Lin, Y.F.,Nguyen, J.T.,Howitz, W.J.,Diab, M.N.,Hamza, I.L.,Lai, J.R.,Wysocki, V.H.,Nowick, J.S.; Probing differences among A beta oligomers with two triangular trimers derived from A beta.; Proc.Natl.Acad.Sci.USA, 120:e2219216120-e2219216120, 2023; PubMed: 37216514; DOI: 10.1073/pnas.2219216120

Experimental method

X-RAY DIFFRACTION (2.169 Å)