8EAD

Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-177

Summary for 8EAD

• Entry DOI: 10.2210/pdb8ead/pdb
• Descriptor: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, N-{2-chloro-5-[(5-methyl-2-{4-[2-(pyrrolidin-1-yl)ethoxy]anilino}pyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide, ... (4 entities in total)
• Functional Keywords: bet, jak2, dual brd-kinase inhibitor, gene regulation
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15782.64

Authors

Karim, M.R.,Schonbrunn, E. (deposition date: 2022-08-29, release date: 2022-09-07, Last modification date: 2023-10-18)

• Primary citation: Karim, M.R.,Schonbrunn, E.; Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-177; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.65 Å)