8EA7
NKG2D complexed with inhibitor 3g
Summary for 8EA7
Entry DOI | 10.2210/pdb8ea7/pdb |
Descriptor | NKG2-D type II integral membrane protein, DI(HYDROXYETHYL)ETHER, (4M)-N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4-(1-methyl-1H-pyrazol-5-yl)-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, ... (4 entities in total) |
Functional Keywords | nkg2d, immune system, immunosuppressant, immunosuppressant-inhibitor complex, immunosuppressant/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 30548.42 |
Authors | Thompson, A.A.,Grant, J.C.,Karpowich, N.K.,Sharma, S. (deposition date: 2022-08-28, release date: 2023-05-03, Last modification date: 2023-05-10) |
Primary citation | Thompson, A.A.,Harbut, M.B.,Kung, P.P.,Karpowich, N.K.,Branson, J.D.,Grant, J.C.,Hagan, D.,Pascual, H.A.,Bai, G.,Zavareh, R.B.,Coate, H.R.,Collins, B.C.,Cote, M.,Gelin, C.F.,Damm-Ganamet, K.L.,Gholami, H.,Huff, A.R.,Limon, L.,Lumb, K.J.,Mak, P.A.,Nakafuku, K.M.,Price, E.V.,Shih, A.Y.,Tootoonchi, M.,Vellore, N.A.,Wang, J.,Wei, N.,Ziff, J.,Berger, S.B.,Edwards, J.P.,Gardet, A.,Sun, S.,Towne, J.E.,Venable, J.D.,Shi, Z.,Venkatesan, H.,Rives, M.L.,Sharma, S.,Shireman, B.T.,Allen, S.J. Identification of small-molecule protein-protein interaction inhibitors for NKG2D. Proc.Natl.Acad.Sci.USA, 120:e2216342120-e2216342120, 2023 Cited by PubMed: 37098070DOI: 10.1073/pnas.2216342120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.28 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)