8E8A

Human DNA polymerase eta-DNA-dT-ended primer binary complex

Summary for 8E8A

• Entry DOI: 10.2210/pdb8e8a/pdb
• Descriptor: DNA polymerase eta, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (4 entities in total)
• Functional Keywords: dna polymerase, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 54681.72

Authors

Chang, C.,Gao, Y. (deposition date: 2022-08-25, release date: 2023-02-01, Last modification date: 2023-10-25)

• Primary citation: Chang, C.,Lee Luo, C.,Eleraky, S.,Lin, A.,Zhou, G.,Gao, Y.; Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity.; J.Biol.Chem., 299:102938-102938, 2023; PubMed: 36702254; DOI: 10.1016/j.jbc.2023.102938

Experimental method

X-RAY DIFFRACTION (1.8 Å)