8E7P
Staphylococcus aureus ClpP in complex with compound 3421
Summary for 8E7P
Entry DOI | 10.2210/pdb8e7p/pdb |
Related | 8E71 |
Descriptor | ATP-dependent Clp protease proteolytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL, (5R,6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-8-[(naphthalen-1-yl)methyl]-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide, ... (4 entities in total) |
Functional Keywords | clpp, cytosolic protein, hydrolase |
Biological source | Staphylococcus aureus subsp. aureus NCTC 8325 |
Total number of polymer chains | 14 |
Total formula weight | 325412.43 |
Authors | Lee, R.E.,Griffith, E.C. (deposition date: 2022-08-24, release date: 2023-07-05, Last modification date: 2023-10-25) |
Primary citation | Singh, A.C.,Zhao, Y.,Griffith, E.C.,Tangallapally, R.,Jarret, M.W.,Lee, R.E. Development of a high throughput and site specific, fluorescent polarization assay to screen for activators of Caseinolytic Protease P leads to the discovery of synthetically tractable new activator class To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.68 Å) |
Structure validation
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