8E4S

The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023034

Summary for 8E4S

Entry DOI	10.2210/pdb8e4s/pdb
Descriptor	Polymerase acidic protein, MANGANESE (II) ION, 5-hydroxy-6-oxo-N-[2-(pyridin-4-yl)ethyl]-2-{[2-(trifluoromethyl)phenyl]methyl}-3,6-dihydropyrimidine-4-carboxamide, ... (6 entities in total)
Functional Keywords	nuclease, influenza, inhibitor resistance, viral protein
Biological source	Influenza A virus (A/Luxembourg/43/2009(H1N1)) More
Total number of polymer chains	1
Total formula weight	24525.53
Authors	Cuypers, M.G.,Slavish, J.P.,Rankovic, Z.,White, S.W. (deposition date: 2022-08-18, release date: 2022-09-21, Last modification date: 2024-04-03)
Primary citation	Slavish, P.J.,Cuypers, M.G.,Rimmer, M.A.,Abdolvahabi, A.,Jeevan, T.,Kumar, G.,Jarusiewicz, J.A.,Vaithiyalingam, S.,Jones, J.C.,Bowling, J.J.,Price, J.E.,DuBois, R.M.,Min, J.,Webby, R.J.,Rankovic, Z.,White, S.W. Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247:115035-115035, 2023 Cited by PubMed: 36603507 DOI: 10.1016/j.ejmech.2022.115035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation