8E4R
Room-temperature X-ray structure of SARS-CoV-2 main protease H41A miniprecursor mutant in complex with GC373
Summary for 8E4R
Entry DOI | 10.2210/pdb8e4r/pdb |
Related | 8E4J |
Descriptor | Replicase polyprotein 1ab, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total) |
Functional Keywords | homodimer, cysteine protease, precursor enzyme, h41a mutation, hydrolase |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 2 |
Total formula weight | 69977.63 |
Authors | Coates, L.,Kneller, D.W.,Kovalevsky, A. (deposition date: 2022-08-18, release date: 2022-11-23, Last modification date: 2023-10-25) |
Primary citation | Kovalevsky, A.,Coates, L.,Kneller, D.W.,Ghirlando, R.,Aniana, A.,Nashed, N.T.,Louis, J.M. Unmasking the Conformational Stability and Inhibitor Binding to SARS-CoV-2 Main Protease Active Site Mutants and Miniprecursor. J.Mol.Biol., 434:167876-167876, 2022 Cited by PubMed: 36334779DOI: 10.1016/j.jmb.2022.167876 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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