8E4P

Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state

8E4P の概要

• エントリーDOI: 10.2210/pdb8e4p/pdb
• EMDBエントリー: 27895
• 分子名称: Transient receptor potential cation channel subfamily M member 8, CHOLESTEROL HEMISUCCINATE (2 entities in total)
• 機能のキーワード: trpm8, menthol receptor, cold receptor, cold sensor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, membrane protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 532033.96

構造登録者

Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.-Y. (登録日: 2022-08-18, 公開日: 2022-10-26, 最終更新日: 2024-06-12)

• 主引用文献: Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.Y.; Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.; Science, 378:eadd1268-eadd1268, 2022; PubMed: 36227998; DOI: 10.1126/science.add1268

実験手法

ELECTRON MICROSCOPY (3.59 Å)