8E4M
The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2
Summary for 8E4M
Entry DOI | 10.2210/pdb8e4m/pdb |
EMDB information | 27892 |
Descriptor | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, nonyl(oxo)di(propan-2-yl)-lambda~5~-phosphane, ... (4 entities in total) |
Functional Keywords | trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, membrane protein |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 4 |
Total formula weight | 530381.41 |
Authors | Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.-Y. (deposition date: 2022-08-18, release date: 2022-10-26, Last modification date: 2024-06-12) |
Primary citation | Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.Y. Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378:eadd1268-eadd1268, 2022 Cited by PubMed: 36227998DOI: 10.1126/science.add1268 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.44 Å) |
Structure validation
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