8E4J

Room-temperature X-ray structure of SARS-CoV-2 main protease H41A miniprecursor mutant

Summary for 8E4J

Entry DOI	10.2210/pdb8e4j/pdb
Descriptor	Replicase polyprotein 1ab (2 entities in total)
Functional Keywords	homodimer, cysteine protease, precursor enzyme, h41a mutation, hydrolase
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	2
Total formula weight	69006.52
Authors	Coates, L.,Kneller, D.W.,Kovalevsky, A. (deposition date: 2022-08-18, release date: 2022-11-23, Last modification date: 2023-10-25)
Primary citation	Kovalevsky, A.,Coates, L.,Kneller, D.W.,Ghirlando, R.,Aniana, A.,Nashed, N.T.,Louis, J.M. Unmasking the Conformational Stability and Inhibitor Binding to SARS-CoV-2 Main Protease Active Site Mutants and Miniprecursor. J.Mol.Biol., 434:167876-167876, 2022 Cited by PubMed: 36334779 DOI: 10.1016/j.jmb.2022.167876 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation