8E3N
Crystal structure of pregnane X receptor ligand binding domain complexed with rifamycin S
Summary for 8E3N
Entry DOI | 10.2210/pdb8e3n/pdb |
Descriptor | Nuclear receptor subfamily 1 group I member 2, Rifamycin S (3 entities in total) |
Functional Keywords | nuclear receptor, transcription factor, metabolism, antibiotic, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 36904.49 |
Authors | Huber, A.D.,Poudel, S.,Seetharaman, J.,Miller, D.J.,Lin, W.,Chen, T. (deposition date: 2022-08-17, release date: 2023-03-15, Last modification date: 2023-10-25) |
Primary citation | Lin, W.,Huber, A.D.,Poudel, S.,Li, Y.,Seetharaman, J.,Miller, D.J.,Chen, T. Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein. Proc.Natl.Acad.Sci.USA, 120:e2217804120-e2217804120, 2023 Cited by PubMed: 36848571DOI: 10.1073/pnas.2217804120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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