8E3G

BMP2/GDF5 heterodimer

8E3G の概要

• エントリーDOI: 10.2210/pdb8e3g/pdb
• 分子名称: Bone morphogenetic protein 2, Growth/differentiation factor 5, GLYCEROL (3 entities in total)
• 機能のキーワード: cystine-knot growth factor heterodimer, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 53505.45

構造登録者

Gipson, G.R.,Nolan, K.T.,Thompson, T.B. (登録日: 2022-08-17, 公開日: 2023-02-15, 最終更新日: 2024-11-06)

主引用文献

Gipson, G.R.,Nolan, K.,Kattamuri, C.,Kenny, A.P.,Agricola, Z.,Edwards, N.A.,Zinski, J.,Czepnik, M.,Mullins, M.C.,Zorn, A.M.,Thompson, T.B.
Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers.
Bmc Biol., 21:16-16, 2023

PubMed Abstract: Proteins of the TGFβ family, which are largely studied as homodimers, are also known to form heterodimers with biological activity distinct from their component homodimers. For instance, heterodimers of bone morphogenetic proteins, including BMP2/BMP7, BMP2/BMP6, and BMP9/BMP10, among others, have illustrated the importance of these heterodimeric proteins within the context of TGFβ signaling.

PubMed: 36726183
DOI: 10.1186/s12915-023-01522-4

実験手法

X-RAY DIFFRACTION (2.8 Å)