8DY5
Crystal Structure of spFv CAT2200 LH in complex with IL-17A
Summary for 8DY5
Entry DOI | 10.2210/pdb8dy5/pdb |
Descriptor | spFv CAT2200 LH, Interleukin-17A, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | scfv, stapled scfv, spfv, germline scfv, single chain fv, scfv stabilizations, antibody, immune system, antibody antigen complex |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 81562.24 |
Authors | Luo, J.,Boucher, L.E. (deposition date: 2022-08-03, release date: 2023-05-03, Last modification date: 2023-10-25) |
Primary citation | Boucher, L.E.,Prinslow, E.G.,Feldkamp, M.,Yi, F.,Nanjunda, R.,Wu, S.J.,Liu, T.,Lacy, E.R.,Jacobs, S.,Kozlyuk, N.,Del Rosario, B.,Wu, B.,Aquino, P.,Davidson, R.C.,Heyne, S.,Mazzanti, N.,Testa, J.,Diem, M.D.,Gorre, E.,Mahan, A.,Nanda, H.,Gunawardena, H.P.,Gervais, A.,Armstrong, A.A.,Teplyakov, A.,Huang, C.,Zwolak, A.,Chowdhury, P.,Cheung, W.C.,Luo, J. "Stapling" scFv for multispecific biotherapeutics of superior properties. Mabs, 15:2195517-2195517, 2023 Cited by PubMed: 37074212DOI: 10.1080/19420862.2023.2195517 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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