8DUL

Cryo-EM Structure of Antibody SKT05 in complex with Western Equine Encephalitis Virus spike (local refinement from VLP particles)

8DUL の概要

• エントリーDOI: 10.2210/pdb8dul/pdb
• EMDBエントリー: 27722
• 分子名称: Spike glycoprotein E2, Spike glycoprotein E1, Antibody Fab SKT05 heavy chain, ... (6 entities in total)
• 機能のキーワード: antibody, skt05, western equine encephalitis virus, broadly neutralizing, immune system
• 由来する生物種: Western equine encephalitis virus; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 345547.66

構造登録者

Cerutti, G.,Verardi, R.,Roederer, M.,Shapiro, L. (登録日: 2022-07-27, 公開日: 2023-07-05)

• 主引用文献: Sutton, M.S.,Pletnev, S.,Callahan, V.,Ko, S.,Tsybovsky, Y.,Bylund, T.,Casner, R.G.,Cerutti, G.,Gardner, C.L.,Guirguis, V.,Verardi, R.,Zhang, B.,Ambrozak, D.,Beddall, M.,Lei, H.,Yang, E.S.,Liu, T.,Henry, A.R.,Rawi, R.,Schon, A.,Schramm, C.A.,Shen, C.H.,Shi, W.,Stephens, T.,Yang, Y.,Florez, M.B.,Ledgerwood, J.E.,Burke, C.W.,Shapiro, L.,Fox, J.M.,Kwong, P.D.,Roederer, M.; Vaccine elicitation and structural basis for antibody protection against alphaviruses.; Cell, 186:2672-2689.e25, 2023; PubMed: 37295404; DOI: 10.1016/j.cell.2023.05.019

実験手法

ELECTRON MICROSCOPY (4.17 Å)