8DT3

Cryo-EM structure of spike binding to Fab of neutralizing antibody (locally refined)

8DT3 の概要

• エントリーDOI: 10.2210/pdb8dt3/pdb
• EMDBエントリー: 27690
• 分子名称: Spike glycoprotein, Heavy chain Fab of SW186, Light chain Fab of SW186, ... (4 entities in total)
• 機能のキーワード: sars-cov2, antibody, neutralizing, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 192781.59

構造登録者

Sun, P.C.,Fang, Y.,Bai, X.C.,Chen, Z.J. (登録日: 2022-07-25, 公開日: 2022-08-03, 最終更新日: 2022-11-09)

• 主引用文献: Fang, Y.,Sun, P.,Xie, X.,Du, M.,Du, F.,Ye, J.,Kalveram, B.K.,Plante, J.A.,Plante, K.S.,Li, B.,Bai, X.C.,Shi, P.Y.,Chen, Z.J.; An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif.; Sci Immunol, 7:eabp9962-eabp9962, 2022; PubMed: 35926067; DOI: 10.1126/sciimmunol.abp9962

実験手法

ELECTRON MICROSCOPY (3.3 Å)