8DSO

Structure of cIAP1, BTK and BCCov

Summary for 8DSO

• Entry DOI: 10.2210/pdb8dso/pdb
• Related: 8DSF
• Descriptor: Tyrosine-protein kinase BTK, Baculoviral IAP repeat-containing protein 2, (4S)-4-[2-(2-{4-[(2E)-4-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}-4-oxobut-2-en-1-yl]piperazin-1-yl}ethoxy)acetamido]-1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-L-prolinamide bound form, ... (5 entities in total)
• Functional Keywords: e3 ligase, protac, ternary complex, btk, oncoprotein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 44605.33

Authors

Schiemer, J.S.,Calabrese, M.F. (deposition date: 2022-07-22, release date: 2023-03-08, Last modification date: 2024-05-01)

• Primary citation: Schiemer, J.,Maxwell, A.,Horst, R.,Liu, S.,Uccello, D.P.,Borzilleri, K.,Rajamohan, N.,Brown, M.F.,Calabrese, M.F.; A covalent BTK ternary complex compatible with targeted protein degradation.; Nat Commun, 14:1189-1189, 2023; PubMed: 36864023; DOI: 10.1038/s41467-023-36738-z

Experimental method

X-RAY DIFFRACTION (2.334 Å)