8DSO
Structure of cIAP1, BTK and BCCov
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Tyrosine-protein kinase BTK | polymer | 277 | 32112.8 | 1 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | B (D) | Baculoviral IAP repeat-containing protein 2 | polymer | 99 | 11318.7 | 1 | UniProt (Q13490) Pfam (PF00653) | Homo sapiens (human) | Cellular inhibitor of apoptosis 1,C-IAP1,IAP homolog B,Inhibitor of apoptosis protein 2,hIAP2,RING finger protein 48,RING-type E3 ubiquitin transferase BIRC2,TNFR2-TRAF-signaling complex protein 2 |
| 3 | C (B) | (4S)-4-[2-(2-{4-[(2E)-4-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}-4-oxobut-2-en-1-yl]piperazin-1-yl}ethoxy)acetamido]-1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-L-prolinamide bound form | non-polymer | 1108.4 | 1 | Chemie (TOO) | |||
| 4 | D (D) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, F (B, D) | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
B: 384 - 659 (UniProt: Q06187)
D: 260 - 352 (UniProt: Q13490)
| PDB | External Database | Details |
|---|---|---|
| Ser 383 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 254 | - | expression tag |
| Ser 255 | - | expression tag |
| Gly 256 | - | expression tag |
| Pro 257 | - | expression tag |
| Gly 258 | - | expression tag |
| Ser 259 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43431.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1173.8 | |
| All* | Total formula weight | 44605.3 |
