8DS5

X-ray structure of the MK5890 Fab - CD27 antibody-antigen complex

Summary for 8DS5

• Entry DOI: 10.2210/pdb8ds5/pdb
• Descriptor: CD27 antigen, MK-5890 Fab light chain, MK-5890 Fab heavy chain, ... (6 entities in total)
• Functional Keywords: complex, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 66905.52

Authors

Fischmann, T.O. (deposition date: 2022-07-21, release date: 2022-09-28, Last modification date: 2024-10-30)

Primary citation

Guelen, L.,Fischmann, T.O.,Wong, J.,Mauze, S.,Guadagnoli, M.,Babala, N.,Wagenaars, J.,Juan, V.,Rosen, D.,Prosise, W.,Habraken, M.,Lodewijks, I.,Gu, D.,Stammen-Vogelzangs, J.,Yu, Y.,Baker, J.,Lutje Hulsik, D.,Driessen-Engels, L.,Malashock, D.,Kreijtz, J.,Bertens, A.,de Vries, E.,Bovens, A.,Bramer, A.,Zhang, Y.,Wnek, R.,Troth, S.,Chartash, E.,Dobrenkov, K.,Sadekova, S.,van Elsas, A.,Cheung, J.K.,Fayadat-Dilman, L.,Borst, J.,Beebe, A.M.,Van Eenennaam, H.
Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy.
J Immunother Cancer, 10:-, 2022

PubMed Abstract: Immune checkpoint inhibitors (ICI) have radically changed cancer therapy, but most patients with cancer are unresponsive or relapse after treatment. MK-5890 is a CD27 agonist antibody intended to complement ICI therapy. CD27 is a member of the tumor necrosis factor receptor superfamily that plays a critical role in promoting responses of T cells, B cells and NK cells.

PubMed: 36100308
DOI: 10.1136/jitc-2022-005049

Experimental method

X-RAY DIFFRACTION (1.926 Å)