8DS1

Structure of SARS-CoV-2 Mpro in complex with nsp12-nsp13 (C12) cut site sequence

Summary for 8DS1

Entry DOI	10.2210/pdb8ds1/pdb
Descriptor	3C-like proteinase nsp5, SODIUM ION, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
Functional Keywords	viral protease, sars-cov-2, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	12
Total formula weight	407237.47
Authors	Lee, J.,Kenward, C.,Worrall, L.J.,Vuckovic, M.,Paetzel, M.,Strynadka, N.C.J. (deposition date: 2022-07-21, release date: 2022-09-28, Last modification date: 2023-10-18)
Primary citation	Lee, J.,Kenward, C.,Worrall, L.J.,Vuckovic, M.,Gentile, F.,Ton, A.T.,Ng, M.,Cherkasov, A.,Strynadka, N.C.J.,Paetzel, M. X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation. Nat Commun, 13:5196-5196, 2022 Cited by PubMed: 36057636 DOI: 10.1038/s41467-022-32854-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation