8DRZ
Product structure of SARS-CoV-2 Mpro C145A mutant in complex with nsp13-nsp14 (C13) cut site sequence
Summary for 8DRZ
Entry DOI | 10.2210/pdb8drz/pdb |
Descriptor | 3C-like proteinase nsp5, DI(HYDROXYETHYL)ETHER, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (6 entities in total) |
Functional Keywords | viral protease, sars-cov-2, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 7 |
Total formula weight | 239693.04 |
Authors | Lee, J.,Kenward, C.,Worrall, L.J.,Vuckovic, M.,Paetzel, M.,Strynadka, N.C.J. (deposition date: 2022-07-21, release date: 2022-09-28, Last modification date: 2023-10-18) |
Primary citation | Lee, J.,Kenward, C.,Worrall, L.J.,Vuckovic, M.,Gentile, F.,Ton, A.T.,Ng, M.,Cherkasov, A.,Strynadka, N.C.J.,Paetzel, M. X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation. Nat Commun, 13:5196-5196, 2022 Cited by PubMed: 36057636DOI: 10.1038/s41467-022-32854-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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