8DRW

Product structure of SARS-CoV-2 Mpro C145A mutant in complex with nsp9-nsp10 (C9) cut site sequence

Summary for 8DRW

• Entry DOI: 10.2210/pdb8drw/pdb
• Descriptor: Fusion protein of 3C-like proteinase nsp5 and nsp9-nsp10 (C9) cut site, SODIUM ION, PENTAETHYLENE GLYCOL, ... (6 entities in total)
• Functional Keywords: viral protease, sars-cov-2, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, 2019-nCoV); More
• Total number of polymer chains: 14
• Total formula weight: 485394.70

Authors

Lee, J.,Kenward, C.,Worrall, L.J.,Vuckovic, M.,Paetzel, M.,Strynadka, N.C.J. (deposition date: 2022-07-21, release date: 2022-09-21, Last modification date: 2023-10-18)

• Primary citation: Lee, J.,Kenward, C.,Worrall, L.J.,Vuckovic, M.,Gentile, F.,Ton, A.T.,Ng, M.,Cherkasov, A.,Strynadka, N.C.J.,Paetzel, M.; X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation.; Nat Commun, 13:5196-5196, 2022; PubMed: 36057636; DOI: 10.1038/s41467-022-32854-4

Experimental method

X-RAY DIFFRACTION (2.67 Å)