8DQT

Human PDK1 kinase domain in complex with Valsartan

8DQT の概要

• エントリーDOI: 10.2210/pdb8dqt/pdb
• 関連するPDBエントリー: 3HRC 3HRF 4AW1
• 分子名称: 3-phosphoinositide-dependent protein kinase 1, (2~{S})-3-methyl-2-[pentanoyl-[[4-[2-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: agc kinase, phosphorylation, pdk1, pif-pocket, alpha-c helix, phosphoprotein, serine/threonine-protein kinase, kinase transferase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36791.22

構造登録者

Gross, L.Z.F.,Klinke, S.,Biondi, R.M. (登録日: 2022-07-19, 公開日: 2023-06-21, 最終更新日: 2023-10-25)

• 主引用文献: Sacerdoti, M.,Gross, L.Z.F.,Riley, A.M.,Zehnder, K.,Ghode, A.,Klinke, S.,Anand, G.S.,Paris, K.,Winkel, A.,Herbrand, A.K.,Godage, H.Y.,Cozier, G.E.,Suss, E.,Schulze, J.O.,Pastor-Flores, D.,Bollini, M.,Cappellari, M.V.,Svergun, D.,Grawert, M.A.,Aramendia, P.F.,Leroux, A.E.,Potter, B.V.L.,Camacho, C.J.,Biondi, R.M.; Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein.; Sci.Signal., 16:eadd3184-eadd3184, 2023; PubMed: 37311034; DOI: 10.1126/scisignal.add3184

実験手法

X-RAY DIFFRACTION (1.31 Å)