8DQJ
Crystal structure of pyrrolysyl-tRNA synthetase from Methanomethylophilus alvus engineered for acridone amino acid (AST) bound to ATP and acridone
Summary for 8DQJ
Entry DOI | 10.2210/pdb8dqj/pdb |
Related | 8DQG 8DQH 8DQI |
Descriptor | AA_TRNA_LIGASE_II domain-containing protein, ADENOSINE-5'-TRIPHOSPHATE, (2~{S})-2-azanyl-3-(9-oxidanylidene-10~{H}-acridin-2-yl)propanoic acid, ... (8 entities in total) |
Functional Keywords | genetic code expansion, methanomethylophilus alvus, pyrrolysyl-trna synthetase, acridone, ligase |
Biological source | Candidatus Methanomethylophilus alvus |
Total number of polymer chains | 2 |
Total formula weight | 62910.66 |
Authors | Gottfried-Lee, I.,Karplus, P.A.,Mehl, R.A.,Cooley, R.B. (deposition date: 2022-07-19, release date: 2022-12-07, Last modification date: 2023-10-25) |
Primary citation | Gottfried-Lee, I.,Perona, J.J.,Karplus, P.A.,Mehl, R.A.,Cooley, R.B. Structures of Methanomethylophilus alvus Pyrrolysine tRNA-Synthetases Support the Need for De Novo Selections When Altering the Substrate Specificity. Acs Chem.Biol., 17:3470-3477, 2022 Cited by PubMed: 36395426DOI: 10.1021/acschembio.2c00640 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
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