8DNJ
Crystal structure of human KRAS G12C covalently bound with AstraZeneca WO2020/178282A1 compound 76
Summary for 8DNJ
Entry DOI | 10.2210/pdb8dnj/pdb |
Related | 8DNI |
Descriptor | Isoform 2B of GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | inhibitor, gtpase, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 66090.77 |
Authors | Mohr, C. (deposition date: 2022-07-11, release date: 2022-08-17, Last modification date: 2023-10-18) |
Primary citation | Zhu, K.,Li, C.,Wu, K.Y.,Mohr, C.,Li, X.,Lanman, B. Modeling receptor flexibility in the structure-based design of KRAS G12C inhibitors. J.Comput.Aided Mol.Des., 36:591-604, 2022 Cited by PubMed: 35930206DOI: 10.1007/s10822-022-00467-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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