8DNI

Crystal structure of human KRAS G12C covalently bound with Araxes WO2020/028706A1 compound I-1

Summary for 8DNI

Entry DOI	10.2210/pdb8dni/pdb
Descriptor	GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	inhibitor, gtpase, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	21976.69
Authors	Mohr, C. (deposition date: 2022-07-11, release date: 2022-08-17, Last modification date: 2023-10-18)
Primary citation	Zhu, K.,Li, C.,Wu, K.Y.,Mohr, C.,Li, X.,Lanman, B. Modeling receptor flexibility in the structure-based design of KRAS G12C inhibitors. J.Comput.Aided Mol.Des., 36:591-604, 2022 Cited by PubMed: 35930206 DOI: 10.1007/s10822-022-00467-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation