8DMM

Structure of the vanadate-trapped MsbA bound to KDL

Summary for 8DMM

• Entry DOI: 10.2210/pdb8dmm/pdb
• Related: 8DHY
• EMDB information: 27544 27545
• Descriptor: ATP-binding transport protein MsbA, ADP ORTHOVANADATE, (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid (3 entities in total)
• Functional Keywords: abc transporter, transport protein
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 134652.69

Authors

Liu, C.,Lyu, J.,Laganowsky, A.D.,Zhao, M. (deposition date: 2022-07-08, release date: 2022-12-14, Last modification date: 2024-06-12)

• Primary citation: Lyu, J.,Liu, C.,Zhang, T.,Schrecke, S.,Elam, N.P.,Packianathan, C.,Hochberg, G.K.A.,Russell, D.,Zhao, M.,Laganowsky, A.; Structural basis for lipid and copper regulation of the ABC transporter MsbA.; Nat Commun, 13:7291-7291, 2022; PubMed: 36435815; DOI: 10.1038/s41467-022-34905-2

Experimental method