8DKS

IRAK4 IN COMPLEX WITH COMPOUND #3

8DKS の概要

• エントリーDOI: 10.2210/pdb8dks/pdb
• 分子名称: Interleukin-1 receptor-associated kinase 4, (1S,2S,3R,4R)-3-({2-[3-(pyrrolidine-1-carbonyl)anilino]thieno[3,2-d]pyrimidin-4-yl}amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide, BETA-MERCAPTOETHANOL, ... (4 entities in total)
• 機能のキーワード: kinase inhibitor, irak4, pyrimidine, atp binding, protein binding, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 104444.48

構造登録者

Chen, Y.,Lin, N. (登録日: 2022-07-06, 公開日: 2022-08-03, 最終更新日: 2022-08-17)

• 主引用文献: Chen, Y.,Tso, K.,Heckrodt, T.J.,Li, H.,Yen, R.,Lin, N.,Singh, R.,Taylor, V.,Masuda, E.S.,Park, G.,Payan, D.G.; Bicyclic pyrimidine compounds as potent IRAK4 inhibitors.; Bioorg.Med.Chem.Lett., 73:128900-128900, 2022; PubMed: 35863718; DOI: 10.1016/j.bmcl.2022.128900

実験手法

X-RAY DIFFRACTION (2.45 Å)