8DJD
CRYSTAL STRUCTURE OF GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 3-[(CYCLOPROPYLMETHYL)AMINO] -N-(4-PHENYLPYRIDIN-3-YL)IMIDAZO[1,2-B]PYRIDAZINE-8-CARBOX AMIDE
Summary for 8DJD
Entry DOI | 10.2210/pdb8djd/pdb |
Descriptor | Glycogen synthase kinase-3 beta, 2-[(cyclopropanecarbonyl)amino]-N-(5-phenylpyridin-3-yl)pyridine-4-carboxamide (3 entities in total) |
Functional Keywords | kinase, gsk3b, transferase-transferase inhibitor complex, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 99306.44 |
Authors | Lewis, H.A.,Muckelbauer, J.K. (deposition date: 2022-06-30, release date: 2023-03-22, Last modification date: 2024-04-03) |
Primary citation | Luo, G.,Chen, L.,Jacutin-Porte, S.,Han, Y.,Burton, C.R.,Xiao, H.,Krause, C.M.,Cao, Y.,Liu, N.,Kish, K.,Lewis, H.A.,Macor, J.E.,Dubowchik, G.M. Structure-activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors. Bioorg.Med.Chem.Lett., 81:129143-129143, 2023 Cited by PubMed: 36669575DOI: 10.1016/j.bmcl.2023.129143 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.205 Å) |
Structure validation
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