8DJ0

Crystal structure of NavAb L123T as a basis for the human Nav1.7 Inherited Erythromelalgia I848T mutation

8DJ0 の概要

• エントリーDOI: 10.2210/pdb8dj0/pdb
• 分子名称: Ion transport protein, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ... (4 entities in total)
• 機能のキーワード: voltage-gated sodium channel ion transport protein, membrane protein
• 由来する生物種: Aliarcobacter butzleri RM4018
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34401.70

構造登録者

Wisedchaisri, G.,Gamal El-Din, T.M.,Zheng, N.,Catterall, W.A. (登録日: 2022-06-29, 公開日: 2023-04-12, 最終更新日: 2023-10-25)

• 主引用文献: Wisedchaisri, G.,Gamal El-Din, T.M.,Zheng, N.,Catterall, W.A.; Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7.; Proc.Natl.Acad.Sci.USA, 120:e2219624120-e2219624120, 2023; PubMed: 36996107; DOI: 10.1073/pnas.2219624120

実験手法

X-RAY DIFFRACTION (2.7 Å)