8DFH

Crystal structure of non-neutralizing / interfering human monoclonal antibody 42C3 Fab in complex with MSP1-19

Summary for 8DFH

Entry DOI	10.2210/pdb8dfh/pdb
Descriptor	Merozoite surface protein 1, 42C3 Fab Heavy Chain, 42C3 Fab Light Chain, ... (4 entities in total)
Functional Keywords	merozoite surface protein 1 (msp1), antigenic diversion, plasmodium falciparum, antigen-antibody complex, structural protein-immune system complex, structural protein/immune system
Biological source	Plasmodium falciparum 3D7 More
Total number of polymer chains	3
Total formula weight	60214.98
Authors	Patel, P.N.,Tang, W.K.,Tolia, N.H. (deposition date: 2022-06-22, release date: 2022-10-12, Last modification date: 2023-10-18)
Primary citation	Patel, P.N.,Dickey, T.H.,Hopp, C.S.,Diouf, A.,Tang, W.K.,Long, C.A.,Miura, K.,Crompton, P.D.,Tolia, N.H. Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion. Nat Commun, 13:5888-5888, 2022 Cited by PubMed: 36202833 DOI: 10.1038/s41467-022-33336-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation