8DD5

Crystal structure of KAT6A in complex with inhibitor CTx-648 (PF-9363)

Summary for 8DD5

• Entry DOI: 10.2210/pdb8dd5/pdb
• Descriptor: Histone acetyltransferase KAT6A, 2,6-dimethoxy-N-{4-methoxy-6-[(1H-pyrazol-1-yl)methyl]-1,2-benzoxazol-3-yl}benzene-1-sulfonamide, ZINC ION, ... (4 entities in total)
• Functional Keywords: histone lysine aceyltransferase, inhibitor complex, cancer, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 34241.05

Authors

Greasley, S.E.,Johnson, E.,Brodsky, O. (deposition date: 2022-06-17, release date: 2023-07-05, Last modification date: 2024-11-20)

• Primary citation: Sharma, S.,Chung, J.,Uryu, S.,Rickard, A.,Nady, N.,Cao, J.,Greasley, S.E.,Brodsky, O.,Khan, S.,Wang, H.,Wang, Z.,Zhang, Y.,Tsaparikos, K.,Chen, L.,Mazurek, A.,Lapek, J.,Kung, P.P.,Sutton, S.,Richardson, P.A.,Greenwald, E.,Yamazaki, S.,Jones, R.,Maegley, K.,Bingham, P.,Lam, H.,Stupple, A.E.,Kamal, A.,Chueh, A.,Cuzzupe, A.,Morrow, B.,Ren, B.,Carrasco-Pozo, C.,Tan, T.W.,Bhuva, D.,Allan, E.,Surgenor, E.,Vaillant, F.,Pehlivanoglu, H.,Falk, H.,Whittle, J.,Newman, J.M.,Cursons, J.,Doherty, J.P.,White, K.L.,MacPherson, L.,Devlin, M.,Dennis, M.L.,Hattarki, M.K.,De Silva, M.,Camerino, M.A.,Butler, M.S.,Dolezal, O.,Pilling, P.,Foitzik, R.,Stupple, P.A.,Lagiakos, R.,Walker, S.,Hediyeh-Zadeh, S.,Nuttall, S.,Spall, S.,Charman, S.A.,Connor, T.,Peat, T.S.,Avery, V.M.,Bozikis, Y.E.,Yang, Y.,Zhang, M.,Monahan, B.J.,Voss, A.K.,Thomas, T.,Street, I.P.,Dawson, S.J.,Dawson, M.,Lindeman, G.J.,Davis, M.,Visvader, J.E.,Paul, T.A.; Targeting KAT6A/KAT6B dependencies in breast cancer with a novel selective, orally bioavailable KAT6 inhibitor, CTx-648/PF-9363; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.58 Å)