8DCI
Crystal Structure of a highly resistant HIV-1 protease Clinical isolate PR10x (inhibitor-free)
Summary for 8DCI
Entry DOI | 10.2210/pdb8dci/pdb |
Related | 3PWM 3PWR 6DIL 6DJ2 6DJ5 8DCH |
Descriptor | Protease (2 entities in total) |
Functional Keywords | hiv/aids, hiv protease, drug resistant clinical mutant, evolution of drug resistance, distal mutations, viral protein, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 21569.12 |
Authors | Wong-Sam, A.E.,Wang, Y.-F.,Weber, I.T. (deposition date: 2022-06-16, release date: 2022-10-05, Last modification date: 2023-10-18) |
Primary citation | Wong-Sam, A.,Wang, Y.F.,Kneller, D.W.,Kovalevsky, A.Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics. J.Mol.Graph.Model., 117:108315-108315, 2022 Cited by PubMed: 36108568DOI: 10.1016/j.jmgm.2022.108315 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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