8DCI

Crystal Structure of a highly resistant HIV-1 protease Clinical isolate PR10x (inhibitor-free)

Summary for 8DCI

Entry DOI	10.2210/pdb8dci/pdb
Related	3PWM 3PWR 6DIL 6DJ2 6DJ5 8DCH
Descriptor	Protease (2 entities in total)
Functional Keywords	hiv/aids, hiv protease, drug resistant clinical mutant, evolution of drug resistance, distal mutations, viral protein, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	21569.12
Authors	Wong-Sam, A.E.,Wang, Y.-F.,Weber, I.T. (deposition date: 2022-06-16, release date: 2022-10-05, Last modification date: 2023-10-18)
Primary citation	Wong-Sam, A.,Wang, Y.F.,Kneller, D.W.,Kovalevsky, A.Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics. J.Mol.Graph.Model., 117:108315-108315, 2022 Cited by PubMed: 36108568 DOI: 10.1016/j.jmgm.2022.108315 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation