8DC8
Crystal structure of p53 Y220C covalently bound to azaindole KG13
Summary for 8DC8
Entry DOI | 10.2210/pdb8dc8/pdb |
Descriptor | Cellular tumor antigen p53, 2-methyl-1-[(4P)-3-methyl-4-(2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl]prop-2-en-1-one, bound form, SULFATE ION, ... (6 entities in total) |
Functional Keywords | tp53, tumor suppressor, cell cycle |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 25383.16 |
Authors | Guiley, K.Z.,Shokat, K.M. (deposition date: 2022-06-15, release date: 2022-10-12, Last modification date: 2023-10-25) |
Primary citation | Guiley, K.Z.,Shokat, K.M. A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability. Cancer Discov, 13:56-69, 2023 Cited by PubMed: 36197521DOI: 10.1158/2159-8290.CD-22-0381 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72009735908 Å) |
Structure validation
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