8D7H

Cryo-EM structure of human CLCF1 in complex with CRLF1 and CNTFR alpha

Summary for 8D7H

• Entry DOI: 10.2210/pdb8d7h/pdb
• EMDB information: 27230
• Descriptor: Ciliary neurotrophic factor receptor subunit alpha, Cardiotrophin-like cytokine factor 1, Cytokine receptor-like factor 1, ... (5 entities in total)
• Functional Keywords: cytokine signaling, clcf1, cntfr alpha, crlf1, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 219466.12

Authors

Zhou, Y.,Franklin, M.C. (deposition date: 2022-06-07, release date: 2023-03-29)

• Primary citation: Zhou, Y.,Stevis, P.E.,Cao, J.,Saotome, K.,Wu, J.,Glatman Zaretsky, A.,Haxhinasto, S.,Yancopoulos, G.D.,Murphy, A.J.,Sleeman, M.W.,Olson, W.C.,Franklin, M.C.; Structural insights into the assembly of gp130 family cytokine signaling complexes.; Sci Adv, 9:eade4395-eade4395, 2023; PubMed: 36930708; DOI: 10.1126/sciadv.ade4395

Experimental method

ELECTRON MICROSCOPY (3.4 Å)