8D6J

Human Ago2 bound to miR122(21nt) with PIWI loop swapped to AtAgo10 sequence

Summary for 8D6J

• Entry DOI: 10.2210/pdb8d6j/pdb
• Descriptor: Protein argonaute-2, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3'), MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: argonaute, rnai, microrna, mirna, rna binding protein-rna complex, rna binding protein/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 104291.43

Authors

Xiao, Y.,MacRae, I. (deposition date: 2022-06-06, release date: 2023-05-03, Last modification date: 2023-10-25)

• Primary citation: Xiao, Y.,Liu, T.M.,MacRae, I.J.; A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength.; Embo Rep., 24:e55806-e55806, 2023; PubMed: 37082939; DOI: 10.15252/embr.202255806

Experimental method

X-RAY DIFFRACTION (2.5 Å)