8D3F

Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST

8D3F の概要

• エントリーDOI: 10.2210/pdb8d3f/pdb
• 分子名称: Signal transducer and activator of transcription 1-alpha/beta,Inhibitor of STAT1-dependent transcription TgIST (1 entity in total)
• 機能のキーワード: signal transduction, transcriptional activation, pathogen effector, interferon signaling, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 73359.93

構造登録者

Huang, Z.,Liu, H.,Nix, J.C.,Amarasinghe, G.K.,Sibley, L.D. (登録日: 2022-06-01, 公開日: 2022-07-06, 最終更新日: 2023-10-25)

• 主引用文献: Huang, Z.,Liu, H.,Nix, J.,Xu, R.,Knoverek, C.R.,Bowman, G.R.,Amarasinghe, G.K.,Sibley, L.D.; The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment.; Nat Commun, 13:4047-4047, 2022; PubMed: 35831295; DOI: 10.1038/s41467-022-31720-7

実験手法

X-RAY DIFFRACTION (2.97 Å)