8D35

Crystal structure of SARS-CoV-2 main protease (Mpro) C145A mutant in complex with peptide from human tRNA methyltransferase TRMT1

Summary for 8D35

• Entry DOI: 10.2210/pdb8d35/pdb
• Descriptor: 3C-like proteinase nsp5, tRNA (guanine(26)-N(2))-dimethyltransferase, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: protease, host-virus protein interaction, rna modifying enzyme, viral protein, hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 3
• Total formula weight: 69579.47

Authors

D'Oliviera, A.,Mugridge, J.S. (deposition date: 2022-05-31, release date: 2023-03-01, Last modification date: 2023-11-22)

• Primary citation: D'Oliviera, A.,Dai, X.,Mottaghinia, S.,Geissler, E.P.,Etienne, L.,Zhang, Y.,Mugridge, J.S.; Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease.; Elife, 2023; DOI: 10.7554/eLife.91168.1

Experimental method

X-RAY DIFFRACTION (1.9 Å)