8D35

Crystal structure of SARS-CoV-2 main protease (Mpro) C145A mutant in complex with peptide from human tRNA methyltransferase TRMT1

8D35 の概要

• エントリーDOI: 10.2210/pdb8d35/pdb
• 分子名称: 3C-like proteinase nsp5, tRNA (guanine(26)-N(2))-dimethyltransferase, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: protease, host-virus protein interaction, rna modifying enzyme, viral protein, hydrolase
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 69579.47

構造登録者

D'Oliviera, A.,Mugridge, J.S. (登録日: 2022-05-31, 公開日: 2023-03-01, 最終更新日: 2023-11-22)

• 主引用文献: D'Oliviera, A.,Dai, X.,Mottaghinia, S.,Geissler, E.P.,Etienne, L.,Zhang, Y.,Mugridge, J.S.; Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease.; Elife, 2023; DOI: 10.7554/eLife.91168.1

実験手法

X-RAY DIFFRACTION (1.9 Å)