8D25

Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT530

8D25 の概要

• エントリーDOI: 10.2210/pdb8d25/pdb
• 分子名称: N-acetyltransferase Eis, 1-{2-[(3-chlorophenyl)methoxy]phenyl}-N-[(pyridin-4-yl)methyl]methanamine, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: resistance, aminoglycoside, enzyme, inhibitor, acetyl transfer, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46430.04

構造登録者

Pang, A.H.,Punetha, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (登録日: 2022-05-27, 公開日: 2022-09-14, 最終更新日: 2023-10-18)

• 主引用文献: Pang, A.H.,Green, K.D.,Chandrika, N.T.,Garzan, A.,Punetha, A.,Holbrook, S.Y.L.,Willby, M.J.,Posey, J.E.,Tsodikov, O.V.,Garneau-Tsodikova, S.; Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity.; Eur.J.Med.Chem., 242:114698-114698, 2022; PubMed: 36037791; DOI: 10.1016/j.ejmech.2022.114698

実験手法

X-RAY DIFFRACTION (2.05 Å)