8D21

Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer

8D21 の概要

• エントリーDOI: 10.2210/pdb8d21/pdb
• EMDBエントリー: 27139
• 分子名称: Hemagglutinin HA2 chain, Hemagglutinin HA1 chain, 1B06 Heavy Chain, ... (6 entities in total)
• 機能のキーワード: vrc, immune system, vrc321, fab, stem, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Influenza A virus; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 267249.50

構造登録者

Gorman, J.,Kwong, P.D. (登録日: 2022-05-27, 公開日: 2023-04-12, 最終更新日: 2023-05-03)

• 主引用文献: Andrews, S.F.,Cominsky, L.Y.,Shimberg, G.D.,Gillespie, R.A.,Gorman, J.,Raab, J.E.,Brand, J.,Creanga, A.,Gajjala, S.R.,Narpala, S.,Cheung, C.S.F.,Harris, D.R.,Zhou, T.,Gordon, I.,Holman, L.,Mendoza, F.,Houser, K.V.,Chen, G.L.,Mascola, J.R.,Graham, B.S.,Kwong, P.D.,Widge, A.,Dropulic, L.K.,Ledgerwood, J.E.,Kanekiyo, M.,McDermott, A.B.; An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans.; Sci Transl Med, 15:eade4976-eade4976, 2023; PubMed: 37075126; DOI: 10.1126/scitranslmed.ade4976

実験手法

ELECTRON MICROSCOPY (3.96 Å)