8D0X

Human FUT9 bound to LNnT

8D0X の概要

• エントリーDOI: 10.2210/pdb8d0x/pdb
• 関連するPDBエントリー: 8D0O 8D0P 8D0Q 8D0R 8D0S 8D0U 8D0W
• 分子名称: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose, ... (7 entities in total)
• 機能のキーワード: glycosyltransferase, alpha-(1, 3)-fucosyltransferase, gt 10, gt-b fold, inverting mechanism, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39871.42

構造登録者

Kadirvelraj, R.,Wood, Z.A. (登録日: 2022-05-26, 公開日: 2023-05-24, 最終更新日: 2023-10-25)

• 主引用文献: Kadirvelraj, R.,Boruah, B.M.,Wang, S.,Chapla, D.,Huang, C.,Ramiah, A.,Hudson, K.L.,Prudden, A.R.,Boons, G.J.,Withers, S.G.,Wood, Z.A.,Moremen, K.W.; Structural basis for Lewis antigen synthesis by the alpha 1,3-fucosyltransferase FUT9.; Nat.Chem.Biol., 19:1022-1030, 2023; PubMed: 37202521; DOI: 10.1038/s41589-023-01345-y

実験手法

X-RAY DIFFRACTION (1.33 Å)