8D0J
Apo Human SARM1 TIR domain
Summary for 8D0J
Entry DOI | 10.2210/pdb8d0j/pdb |
Related | 8D0C 8D0D 8D0E 8D0F 8D0G 8D0H 8D0I 8D0M |
Descriptor | NAD(+) hydrolase SARM1 (2 entities in total) |
Functional Keywords | nad, hydrolase, axon degeneration, neuroscience |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 32411.15 |
Authors | Bratkowski, M.A.,Mathur, P. (deposition date: 2022-05-26, release date: 2022-09-21, Last modification date: 2024-04-03) |
Primary citation | Bratkowski, M.,Burdett, T.C.,Danao, J.,Wang, X.,Mathur, P.,Gu, W.,Beckstead, J.A.,Talreja, S.,Yang, Y.S.,Danko, G.,Park, J.H.,Walton, M.,Brown, S.P.,Tegley, C.M.,Joseph, P.R.B.,Reynolds, C.H.,Sambashivan, S. Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease. Neuron, 110:3711-, 2022 Cited by PubMed: 36087583DOI: 10.1016/j.neuron.2022.08.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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