8D0G

Human SARM1 TIR domain bound to NB-3-ADPRP

8D0G の概要

• エントリーDOI: 10.2210/pdb8d0g/pdb
• 関連するPDBエントリー: 8D0C 8D0D 8D0E 8D0F 8D0H 8D0I 8D0J 8D0M
• 分子名称: NAD(+) hydrolase SARM1, [[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-[4-[(1~{S})-1-[methyl-[2,2,2-tris(fluoranyl)ethylcarbamoyl]amino]ethyl]pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (3 entities in total)
• 機能のキーワード: nad, hydrolase, axon degeneration, neuroscience, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34178.21

構造登録者

Bratkowski, M.A.,Mathur, P. (登録日: 2022-05-26, 公開日: 2022-09-21, 最終更新日: 2023-10-25)

• 主引用文献: Bratkowski, M.,Burdett, T.C.,Danao, J.,Wang, X.,Mathur, P.,Gu, W.,Beckstead, J.A.,Talreja, S.,Yang, Y.S.,Danko, G.,Park, J.H.,Walton, M.,Brown, S.P.,Tegley, C.M.,Joseph, P.R.B.,Reynolds, C.H.,Sambashivan, S.; Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease.; Neuron, 110:3711-, 2022; PubMed: 36087583; DOI: 10.1016/j.neuron.2022.08.017

実験手法

X-RAY DIFFRACTION (1.99 Å)