8CXL

Structure of NapH3, a vanadium-dependent haloperoxidase homolog catalyzing the stereospecific alpha-hydroxyketone rearrangement reaction in napyradiomycin biosynthesis

Summary for 8CXL

Entry DOI	10.2210/pdb8cxl/pdb
Related	3w35 3w36
Descriptor	NapH3, MAGNESIUM ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	vanadium-dependent haloperoxidase, vhpo, alpha-hydroxyketone rearrangement, napyradiomycin, biosynthetic protein
Biological source	Streptomyces sp. CNQ-525
Total number of polymer chains	2
Total formula weight	103610.02
Authors	Chen, P.Y.-T.,Chekan, J.R.,Moore, B.S. (deposition date: 2022-05-21, release date: 2022-08-31, Last modification date: 2023-10-18)
Primary citation	Chen, P.Y.,Adak, S.,Chekan, J.R.,Liscombe, D.K.,Miyanaga, A.,Bernhardt, P.,Diethelm, S.,Fielding, E.N.,George, J.H.,Miles, Z.D.,Murray, L.A.M.,Steele, T.S.,Winter, J.M.,Noel, J.P.,Moore, B.S. Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis. Biochemistry, 61:1844-1852, 2022 Cited by PubMed: 35985031 DOI: 10.1021/acs.biochem.2c00338 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation