8CW9

Prefusion-stabilized hMPV fusion protein bound to ADI-61026 and MPE8 Fabs

8CW9 の概要

• エントリーDOI: 10.2210/pdb8cw9/pdb
• EMDBエントリー: 27024
• 分子名称: Fusion glycoprotein F0, MPE8 light chain, ADI-61026 heavy, ... (6 entities in total)
• 機能のキーワード: site 0 neutralizing antibody, prefusion-stabilized hmpv f protein, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human metapneumovirus; 詳細
• タンパク質・核酸の鎖数: 15
• 化学式量合計: 541479.03

構造登録者

Hsieh, C.-L.,McLellan, J.S. (登録日: 2022-05-18, 公開日: 2022-08-10, 最終更新日: 2023-02-22)

• 主引用文献: Rappazzo, C.G.,Hsieh, C.L.,Rush, S.A.,Esterman, E.S.,Delgado, T.,Geoghegan, J.C.,Wec, A.Z.,Sakharkar, M.,Mas, V.,McLellan, J.S.,Walker, L.M.; Potently neutralizing and protective anti-human metapneumovirus antibodies target diverse sites on the fusion glycoprotein.; Immunity, 55:1710-1724.e8, 2022; PubMed: 35944529; DOI: 10.1016/j.immuni.2022.07.003

実験手法

ELECTRON MICROSCOPY (3.46 Å)